The Saskatchewan Epilepsy Program headed by Dr. José Téllez Zenteno publish two new journal articles

Dr. Rizvi et al. describes the outcomes of the single seizure clinic (SSC) in Saskatoon. This is a prospective study including 200 patients referred to our SSC for first seizure evaluation.  A diagnosis was established at first-contact in 80.5% of cases while 16.0% of patients required a second visit. Eighty-two patients (41.0%) were diagnosed with epilepsy. An abnormal EEG was found in 93.9% of patients diagnosed with epilepsy. Sixty-three patients were started on anti-epileptic drugs (63.5% lamotrigine, 7.0% levetiracetam, 5.0% phenytoin, and 5.0% topiramate). In 18% of cases driving restrictions were initiated by the SSC. The most common non-seizure diagnosis was syncope (24.0%).The SSC reduced wait-times for assessment and investigations, clarified diagnoses, affected management decisions with respect to further workup, pharmacotherapy, and driving. 

http://www.jns-journal.com/article/S0022-510X(16)30329-X/abstract

Single Seizure Clinic Model Effective in Evaluating Epilepsy

Dr. Hernandez-Ronquillo et al. describes the outcomes of a large sample of patients with temporal lobe epilepsy (TLE). The study is a prospective cohort study of all patients with TLE assessed and followed by the Saskatchewan Epilepsy Program, from 1 March 2007 to Jan 29(th) 2014. The cohort consisted of 159 patients. Mean patient age at last follow-up visit was 46±14.4 (range: 19-88) years. Mean follow-up period was 43.4±22.6 (6 to 84) months. Forty-six patients (29%) demonstrated mild-course TLE while 113 (71%) had a severe course of TLE. Patients with a mild course of TLE were more likely to be older (p = 0.002), have late-onset epilepsy (p < 0.001) with shorter evolution (p < 0.001). A good response to the first antiepileptic drug (OR: 6.8; 95% CI: 2.5-19; p < 0.001) was associated with a mild course of TLE. Although a majority of patients with TLE eventually require surgery, operative treatment is not necessary for all patients. This study identifies prognostic factors that may help patients and clinicians characterize long-term outcome. 

How many adults with temporal epilepsy have a mild course and do not require epilepsy surgery? - PubMed - NCBI