Effects of D- and L-govadine on the disruption of touchscreen object-location paired associates learning in rats by acute MK-801 treatment.

Brittney R. Lins, Anthony G. Phillips, John G. Howland

Rationale: New pharmacological treatments for the cognitive deficits in schizophrenia are needed. Tetrahydroprotoberberines, such as govadine, are one class of compounds with dopaminergic activities that may be useful in treating some aspects of the cognitive symptoms of the disorder. 

Psychopharmacology (2015) 232:4371–4382

http://www.ncbi.nlm.nih.gov/pubmed/26359226

Effects of the metabotropic glutamate receptor 5 positive allosteric modulator CDPPB on rats tested with the paired associates learning task in touchscreen-equipped operant conditioning chambers.

Brittney R. Lins, John G. Howland

Effective treatments for the cognitive symptoms of schizophrenia are critically needed. Positive allosteric modulation (PAM) of metabotropic glutamate receptor subtype 5 (mGluR5) is one strategy currently under investigation to improve these symptoms. Examining cognition using touchscreen-equipped operant chambers may increase translation between preclinical and clinical research through analogous behavioral testing paradigms in rodents and humans. We used acute CDPPB (1–30 mg/kg) treatment to examine the effects of mGluR5 PAM in the touchscreen paired associates learning (PAL) task using well-trained rats with and without co-administration of acute MK-801 (0.15 mg/kg). CDPPB had no consistent effects on task performance when administered alone and failed to reverse the MK-801 induced impairments at any of the examined doses. Overall, the disruptive effects of MK-801 on PAL were consistent with previous research but increasing mGluR5 signaling is not beneficial in the PAL task. Future research should test whether administration of CDPPB during PAL acquisition increases performance.

Behavioural Brain Research 301 (2016) 152–160

http://www.ncbi.nlm.nih.gov/pubmed/26721467

Chandna AR, Kuhlmann N, Bryce CA, Greba Q, Campanucci VA, Howland JG (2015). Chronic maternal hyperglycemia induced during mid-pregnancy in rats increases RAGE expression, augments hippocampal excitability, and alters behavior of the offspring. Neuroscience 303:241-260.

Ballendine SA, Greba Q, Dawicki W, Zhang X, Gordon JR, Howland JG (2015). Behavioral alterations in rat offspring following maternal immune activation and ELR-CXC chemokine receptor antagonism during pregnancy: implications for neurodevelopmental psychiatric disorders. Progress in Neuro-Psychopharmacology & Biological Psychiatry 57:155-165.

Bryce CA, Howland JG (2015). Stress facilitates late reversal learning using a touchscreen-based visual discrimination procedure in male Long Evans rats. Behavioural Brain Research 278:21-28.

Sangha S, Greba Q, Robinson PD, Ballendine SA, Howland JG (2014). Heightened fear in response to a safety cue and extinguished fear cue in a rat model of maternal immune activation. Frontiers in Behavioral Neuroscience 8:168.

Sangha S, Robinson PD, Greba Q, Davies DA, Howland JG (2014). Alterations in reward, fear and safety cue discrimination after inactivation of the rat prelimbic and infralimbic cortices. Neuropsychopharmacology 39:2405-2413.

Lins BR, Ballendine SA, Howland JG (2014). Altered object exploration but not temporal order memory retrieval in an object recognition test following treatment of rats with the group II metabotropic glutamate receptor agonist LY379268. Neuroscience Letters 560:41-45.

Davies DA, Greba Q, Howland JG (2013). GluN2B-containing NMDA receptors and AMPA receptors in medial prefrontal cortex are necessary for odor span in rats. Frontiers in Behavioral Neuroscience 7:183. doi: 10.3389/fnbeh.2013.00183.

MacDougall MJ, Howland JG (2013). Acute stress and hippocampal output: exploring dorsal CA1 and subicular plasticity simultaneously in anesthetized rats. Physiological Reports 1:e00035.

Davies DA, Molder JJ, Greba Q, Howland JG (2013). Inactivation of medial prefrontal cortex or acute stress impairs odor span in rats. Learning & Memory 20:665-669.

MacDougall MJ, Howland JG (2013). Acute stress, but not corticosterone, disrupts short- and long-term synaptic plasticity in rat dorsal subiculum via glucocorticoid receptor activation. Cerebral Cortex 23:2611-2619.

Thai CA, Zhang Y, Howland JG (2013). Effects of acute restraint stress on set-shifting and reversal learning in male rats. Cognitive, Affective, and Behavioral Neuroscience 13:164-173.

Dong Z, Bai Y, Wu X, Li H, Gong B, Howland JG, Huang Y, He W, Li T, Wang YT (2013). Hippocampal long-term depression mediates spatial learning in the Morris water maze. Neuropharmacology 64:65-73.

Howland JG, Cazakoff BN, Zhang Y (2012). Altered object-in-place recognition memory, prepulse inhibition, and locomotor activity in the offspring of rats exposed to a viral mimetic during pregnancy. Neuroscience 201:184-198.

Zhang Y, Cazakoff BN, Thai CA, Howland JG (2012). Prenatal exposure to a viral mimetic alters behavioural flexibility in male, but not female, offspring. Neuropharmacology 62:1299-1307.